Minigraph
基于 minimizer 的图基因组构建和比对工具，可将多个基因组组装整合为一个 保留结构变异的图结构。该方法支持线性序列到图的高效比对，是泛基因组 分析的核心工具。
| Property | Value |
|---|---|
| Purpose | 构建泛基因组图和图上比对 |
| Time Complexity | O(n log n) |
| Space Complexity | O(n) |
| Year | 2020 |
| Difficulty | Advanced |
| Languages | C++ |
| Category | Graph Genomics |
Complexity Analysis
- Time Complexity:
O(n log n) - Space Complexity:
O(n)
Performance Insight: The time complexity of this algorithm is quasi-linear (n log n), balancing practical efficiency with theoretical near-optimality. Linear space can often be reduced by constant factors via sliding-window techniques.
Note: Complexity analysis is based on theoretical models. Actual runtime is affected by input scale, hardware, and implementation optimizations. Benchmark for your specific workload.
Literature & Implementation
Related Tools
vg · Minimap2 · PGGB