MuTect2
GATK 中的体细胞变异检测工具，通过贝叶斯统计模型同时检测肿瘤样本中的体细胞 SNP 和小型 Indel。 该方法利用匹配的正常组织样本进行背景噪声去除，广泛应用于癌症基因组学研究与临床肿瘤检测。
| Property | Value |
|---|---|
| Purpose | 检测体细胞 SNP 和小型 Indel 变异 |
| Time Complexity | O(n * r) |
| Space Complexity | O(r) |
| Year | 2013 |
| Category | Variant Calling |
Complexity Analysis
- Time Complexity:
O(n * r) - Space Complexity:
O(r)
Performance Insight: The time complexity of this algorithm is polynomial.
Note: Complexity analysis is based on theoretical models. Actual runtime is affected by input scale, hardware, and implementation optimizations. Benchmark for your specific workload.
Literature & Implementation
Related Tools
GATK · Strelka2 · VarScan2